Primary research interest

  • Molecular toxicology, metabolism and longevity of invertebrates

Researcher biography

Molecular mechanisms of phosphine resistance

Genetic mapping of oxidative stress resistance genes. The fumigant, phosphine, disrupts oxidative metabolism, resulting in the production of reactive oxygen intermediates. This causes the premature ageing and death of targeted pests. Insect pests of stored grain in Australia now exhibit resistance to phosphine at levels more than 200 times the normal lethal dose.

We are using genetic mapping to clone the genes responsible for phosphine resistance in the Lesser Grain Borer.We are also using functional genomics of the model organisms C. elegans to understand the molecular basis of phosphine actionOur genetic studies have recently shown that resistance to phosphine is associated with an extension of lifespan

Areas of research